Zinc for Skin

 

 

Zinc helps your skin heal after an injury. It's needed to keep cell walls stable and for cells to divide and specialize as they grow. Zinc may protect skin from UV damage because of the way it behaves in relation to other metals in your body, like iron and copper. It also acts like an antioxidant.

 

 

Eur J Pharm Biopharm

. 2016 Jul;104:140-7. doi: 10.1016/j.ejpb.2016.04.022. Epub 2016 Apr 27.

Human skin penetration and local effects of topical nano zinc oxide after occlusion and barrier impairment

V R Leite-Silva 1W Y Sanchez 2H Studier 3D C Liu 2Y H Mohammed 2A M Holmes 3E M Ryan 2I N Haridass 2N C Chandrasekaran 2W Becker 4J E Grice 2H A E Benson 5M S Roberts 6

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Nano Zinc used for Topical

Public health concerns continue to exist over the safety of zinc oxide nanoparticles that are commonly used in sunscreen formulations. In this work, we assessed the effects of two conditions which may be encountered in everyday sunscreen use, occlusion and a compromised skin barrier, on the penetration and local toxicity of two topically applied zinc oxide nanoparticle products. Caprylic/capric triglyceride (CCT) suspensions of commercially used zinc oxide nanoparticles, either uncoated or with a silane coating, were applied to intact and barrier impaired skin of volunteers, without and with occlusion for a period of six hours. The exposure time was chosen to simulate normal in-use conditions. Multiphoton tomography with fluorescence lifetime imaging was used to noninvasively assess zinc oxide penetration and cellular metabolic changes that could be indicative of toxicity. We found that zinc oxide nanoparticles did not penetrate into the viable epidermis of intact or barrier impaired skin of volunteers, without or with occlusion. We also observed no apparent toxicity in the viable epidermis below the application sites. These findings were validated by ex vivo human skin studies in which zinc penetration was assessed by multiphoton tomography with fluorescence lifetime imaging as well as Zinpyr-1 staining and toxicity was assessed by MTS assays in zinc oxide treated skin cryosections. In conclusion, applications of zinc oxide nanoparticles under occlusive in-use conditions to volunteers are not associated with any measurable zinc oxide penetration into, or local toxicity in the viable epidermis below the application site.

Keywords: Barrier impairment; In-use application; Occlusion; Safety; Skin penetration; Sunscreens; Toxicity; Zinc oxide nanoparticles.

Copyright © 2016 Elsevier B.V. All rights reserved.

Nano Silver

The nano silver suppresses respiration, basal metabolism of electron transfer system, and transport of substrate in the microbial cell membrane. The nano silver inhibits multiplication and growth of those bacteria and fungi which cause infection, odor, itchiness and sores.